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After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. In this latter situation it may be necessary to increase the dosage of PRELONE (prednisolone ) Syrup for a period of time consistent with the patients condition.
If exposed to chickenpox, prophylaxis with varicella zoster immune globulin may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chickenpox develops,treatment with antiviral agents may be considered. The initial dosage of PRELONE (prednisolone ) Syrup may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted.
Upper Gl X-rays are desirable in patients with known or suspected peptic ulcer disease. Drug-induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles.
The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual. Glucocorticoids such as prednisolone cause profound and varied metabolic effects. Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. You are encouraged to report negative side effects of prescription drugs to the FDA. There is an enhanced effect of corticosteroids on patients with hypothyroidism and in those with cirrhosis.
Get medical help right away, if you have any of the symptoms listed above. Prelone is a prescription medicine used to treat the symptoms of Rheumatoid Arthritis and Multiple Sclerosis.
Patients should also be advised that if they are exposed, medical advice should be sought without delay. Naturally occurring glucocorticoids (hydro-cortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs such as prednisolone are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.
If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued. The severity, prognosis, expected duration of the disease, and the reaction of the patient to medication are primary factors in determining dosage. Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation. Dosage should be decreased or discontinued gradually when the drug has been administered for more than a few days. In addition to the above indications PRELONE (prednisolone ) Syrup is indicated for systemic dermatomyositis . It also contains alcohol 5%, citric acid, edetate disodium, glycerin, propylene glycol, purified water, sodium saccharin, sucrose, artificial wild cherry flavor, FD&C blue #1 and red #40.
Corticosteroids may mask some signs of infection, and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used. Blood pressure, body weight, routine laboratory studies, including two-hour postprandial blood glucose and serum potassium, and a chest X-ray should be obtained at regular intervals during prolonged therapy.
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